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  Improving cognition and daily functioning in Vascular Dementia

Indication
CognivAiD is indicated for patients with mild to moderate vascular dementia.

Composition
CognivAiD is a multi-herbal formulation containing active extracts of 3 ingredients:

Croci Stigma
Ginkgo Folium
Ginseng Radix et Rhizoma

Dosage & administration
The recommended dosage is 2 capsules, 2 times a day orally.

Side effects
Rare cases of headaches, gastrointestinal disturbances or allergic skin reactions.

Precautions
Not recommended in pregnant and lactating women, and in individuals with bleeding tendency or are hypersensitive to ginkgo. Not recommended for concomitant use with anticoagulants/antiplatelets, and before surgery.

 

A targeted multi-modal Action

CognivAiD simultaneously targets the key pathological pathways of vascular dementia.

References:

1. Seto, S., et al. (2017). Sailuotong prevents hydrogen peroxide (H2O2)-induced injury in EA.hy926 cells. International Journal of Molecular Sciences, 18(1), 95. https://doi.org/10.3390/ijms18010095

2. Yeon, S. Y., et al. (2020). Endothelium-Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery. Evidence-Based Complementary and Alternative Medicine, 2020, 1–10. https://doi.org/10.1155/2020/8125805

3. Zhang, Y., et al. (2019). Sailuotong Capsule Prevents the Cerebral Ischaemia-Induced Neuroinflammation and Impairment of Recognition Memory through Inhibition of LCN2 Expression. Oxidative Medicine and Cellular Longevity, 2019, 1–13. https://doi.org/10.1155/2019/8416105

    Sustained Improvement of Functional & Cognitive Domains in
    Vascular Dementia (VaD) With a Favourable Safety Profile

     

    Beneficial as Monotherapy

     

    1. Improves cognitive and executive functions1

    • Significant improvement of cognitive function based on VaDAS-Cog assessment as early as 3 months
    Long-term continuous improvement up to 1 year
    • Reproducible benefits seen in delayed-starter groups after switching from placebo to CognivAiD

     

    VaDAS-Cog: Vascular Dementia Assessment Scale Cognitive subscale

     

    2. Significant & clinically meaningful global improvement1

    Significant improvement in global condition of patients assessed by clinician with input of caregiver, based on ADCS-CGIC
    Divergence of outcomes between early- and delayed-starter groups was reversed as early as 3 months after switching from placebo to CognivAiD in delayed-starter groups
    • Sustained improvement for at least 1 year

     

    ADCS-CGIC: Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change

     

    3. Delays functional decline1

    • CognivAiD reduces the proportion of deteriorating patients by 47%  vs placebo.

     

     


     

    Legend:

    *p<0.05, **p<0.01, ***p<0.001

     

    References

    1. Jia, J., et al. (2018). Efficacy and safety of the compound Chinese medicine SaiLuoTong in vascular dementia: A randomized clinical trial. Alzheimer’s & dementia (New York, N. Y.), 4, 108–117. https://doi.org/10.1016/j.trci.2018.02.004

     

    Beneficial as Add-on

     

    1. Enhances cognition2

    • Significant & clinically meaningful improvement in cognition compared to placebo
    Sustained improvements while receiving CognivAiD

     

    ADAS-Cog: Alzheimer’s Disease Assessment Scale Cognitive subscale

     

    2. Enhances daily functioning2

     CognivAiD nearly doubles the proportion of subjects who improved functionally vs placebo.
    CognivAiD reduces by 38% the proportion of deteriorating subjects vs placebo.

     

    ADCS-CGIC: Alzheimer's Disease Cooperative Study-Activities of Daily Living

     

    3. Improves quality of life2

    CognivAiD nearly triples the proportion of subjects who reported better quality of life vs placebo.

     

    SF-36: Short Form 36 Health Survey Questionnaire

     


     

    Legend:

    *p<0.05, **p<0.01

     

    References

    2. Liu, J., et al. (2022). A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia. Aging medicine (Milton (N.S.W)), 5(4), 246–256. https://doi.org/10.1002/agm2.12230

     

    Safe & Well-Tolerated

     

    1. Safe and well-tolerated

    • No significant difference in rate of adverse events in those taking CognivAiD vs placebo.1,2

     


     

    References

    1. Jia, J., et al. (2018). Efficacy and safety of the compound Chinese medicine SaiLuoTong in vascular dementia: A randomized clinical trial. Alzheimer’s & dementia (New York, N. Y.), 4, 108–117. https://doi.org/10.1016/j.trci.2018.02.004

    2. Liu, J., et al. (2022). A pilot randomized controlled trial of WeiNaoKang (SaiLuoTong) in treating vascular dementia. Aging medicine (Milton (N.S.W)), 5(4), 246–256.  https://doi.org/10.1002/agm2.12230

     

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